Unconjugated Bilirubin Modulates the Intestinal Epithelial Barrier Function in a Human-Derived In Vitro Model

@article{Raimondi2006UnconjugatedBM,
  title={Unconjugated Bilirubin Modulates the Intestinal Epithelial Barrier Function in a Human-Derived In Vitro Model},
  author={Francesco Raimondi and Valeria Crivaro and Letizia Capasso and Luigi Maiuri and Pasquale Santoro and Maria Giovanna Tucci and Maria Vittoria Barone and Serena Pappacoda and Roberto Paludetto},
  journal={Pediatric Research},
  year={2006},
  volume={60},
  pages={30-33}
}
Unconjugated bilirubin promotes intestinal secretion without affecting nutrient digestion or absorption. In the current study, the effects of unconjugated bilirubin (UCB) on the barrier function of the intestinal epithelium were investigated. The apical side of human intestinal cell line Caco-2 monolayers was challenged with purified UCB. Transepithelial electrical resistance and paracellular fluxes of 10 kD Cascade blue conjugate dextran were measured. Cell monolayer viability was studied… CONTINUE READING

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Subcommittee on Hyperbilirubinemia 2004 Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation

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