Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus.

@article{Raedt2009UnconditionedAN,
  title={Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus.},
  author={Robrecht Raedt and Annelies Van Dycke and Anouk A T Waeytens and Tine Wyckhuys and Kristl Vonck and Wytse Wadman and Paul Boon},
  journal={Epilepsy research},
  year={2009},
  volume={87 2-3},
  pages={148-59}
}
PURPOSE Cell transplantation is being investigated as an alternative treatment for medically refractory temporal lobe epilepsy (TLE). In this study the fate of adult-derived neurosphere cells was evaluated after transplantation in the lesioned hippocampus of the intrahippocampal kainic acid (KA) model for TLE. METHODS Neurosphere-forming cells were derived from the subventricular zone (SVZ) of transgenic green fluorescent protein (GFP) reporter mice and expanded in culture. After 10 passages… CONTINUE READING

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