Uncompetitive Antagonists of the N‐Methyl‐D‐aspartate (NMDA) Receptors Alter the mRNA Expression of Proteins Associated with the NMDA Receptor Complex

@article{Linden2001UncompetitiveAO,
  title={Uncompetitive Antagonists of the N‐Methyl‐D‐aspartate (NMDA) Receptors Alter the mRNA Expression of Proteins Associated with the NMDA Receptor Complex},
  author={A. Linden and Jussi V{\"a}is{\"a}nen and M. Storvik and M. Lakso and E. Korpi and G. Wong and E. Castr{\'e}n},
  journal={Pharmacology \& Toxicology},
  year={2001},
  volume={88},
  pages={98-105}
}
N-methyl-D-aspartate (NMDA) receptor function appears to be under complex control during physiological and pharmacological states. We have investigated the effects of acute administration of uncompetitive NMDA receptor antagonists on mRNA levels of NMDA receptor subunits and on molecules known to cluster or phosphorylate the receptor utilizing in situ hybridization on rat brain sections. A high dose (5 mg/kg; 4 hr) of dizocilpine (MK-801) decreased mRNA levels of NMDA receptor subunits NR2C and… Expand
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