Uncommon karyotypic abnormality, t(11;19)(q23;p13.3), in a patient with blastic phase of chronic myeloid leukemia.

@article{Suzuki2004UncommonKA,
  title={Uncommon karyotypic abnormality, t(11;19)(q23;p13.3), in a patient with blastic phase of chronic myeloid leukemia.},
  author={Keijiro Suzuki and Takeshi Sugawara and Shugo Kowata and Taiju Utsugizawa and Shigeki Ito and Kazunori Murai and Yoji Ishida},
  journal={Cancer genetics and cytogenetics},
  year={2004},
  volume={150 2},
  pages={159-63}
}
We describe unusual cytogenetic findings in a 33-year-old male with blastic phase of Philadelphia chromosome (Ph)-positive chronic myeloid leukemia. In addition to the t(9;22)(q34;q11), which was detected in all metaphases, a t(11;19)(q23;p13.3) was also identified as an evolutional change in all 20 metaphases. Fluorescence in situ hybridization (FISH) analysis showed that fusion signals of the ABL/BCR probes were found in 95% of blastic cells. Southern blotting and FISH analysis also revealed… CONTINUE READING