Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.

@article{Brennan2007UncommonCM,
  title={Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.},
  author={Paul Brennan and James McKay and Lee E. Moore and David G. Zaridze and Anush Mukeria and Neonilia Szeszenia-Dabrowska and Jolanta Lissowska and P{\'e}ter Rudnai and Eleon{\'o}ra Fabi{\'a}nov{\'a} and Dana Mateş and Vladim{\'i}r Bencko and Lenka For{\'e}tova and Vladim{\'i}r Janout and Wong-Ho Chow and Nathaniel Rothman and Am{\'e}lie Chabrier and Val{\'e}rie Gaborieau and Fabrice A. Odefrey and Melissa Southey and Mia Hashibe and Janet Hall and Paolo Boffetta and Julian Peto and Richard Peto and Rayjean J Hung},
  journal={Human molecular genetics},
  year={2007},
  volume={16 15},
  pages={1794-801}
}
CHEK2 is a key cell cycle control gene encoding a pluripotent kinase that can cause arrest or apoptosis in response to unrepaired DNA damage. We report a large case-control study of a non-functional variant that had previously been expected to increase cancer rates. Four thousand and fifteen cancer patients (2250 lung, 811 squamous upper aero-digestive and 954 kidney) and 3052 controls in central Europe were genotyped for the mis-sense variant rs17879961 (replacement of T by C), which changes… CONTINUE READING
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