Unchanged sarcoplasmic reticulum Ca2+-ATPase activity, reduced Ca2+ sensitivity, and negative force-frequency relationship in transgenic rats overexpressing the mouse renin gene

Abstract

Transgenic rats overexpressing the mouse Ren-2 gene [TG(mREN2)27 rats, TGR] were used to characterize alterations in force generation and relaxation following cardiac hypertrophy. Age-matched Sprague-Dawley rats were used as the control group. The β-adrenoceptor dependent increase in force of contraction was reduced in the transgenic animals but not the Ca2… (More)
DOI: 10.1007/s001090050247

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@article{Zobel1998UnchangedSR, title={Unchanged sarcoplasmic reticulum Ca2+-ATPase activity, reduced Ca2+ sensitivity, and negative force-frequency relationship in transgenic rats overexpressing the mouse renin gene}, author={Carsten Zobel and Klara Brixius and Markus Pietsch and G{\"{o}tz M{\"{u}nch and Birgit Boelck and Robert H. G. Schwinger}, journal={Journal of Molecular Medicine}, year={1998}, volume={76}, pages={533-544} }