Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology.

@article{Pathmanathan2015UncertaintyQO,
  title={Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology.},
  author={Pras Pathmanathan and Matthew S. Shotwell and David J Gavaghan and Jonathan M. Cordeiro and Richard A. Gray},
  journal={Progress in biophysics and molecular biology},
  year={2015},
  volume={117 1},
  pages={4-18}
}
Perhaps the most mature area of multi-scale systems biology is the modelling of the heart. Current models are grounded in over fifty years of research in the development of biophysically detailed models of the electrophysiology (EP) of cardiac cells, but one aspect which is inadequately addressed is the incorporation of uncertainty and physiological variability. Uncertainty quantification (UQ) is the identification and characterisation of the uncertainty in model parameters derived from… CONTINUE READING