Uncertainty in the niches that maintain haematopoietic stem cells

@article{Kiel2008UncertaintyIT,
  title={Uncertainty in the niches that maintain haematopoietic stem cells},
  author={Mark J. Kiel and Sean J Morrison},
  journal={Nature Reviews Immunology},
  year={2008},
  volume={8},
  pages={290-301}
}
Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain stem cells and regulate their maintenance. Cells at the interface of bone and the bone marrow (the endosteum) contribute to the creation of HSC niches. It remains uncertain whether this interface itself is a niche, or whether endosteal cells secrete factors that diffuse to nearby niches. Vascular and/or perivascular cells may also create niches as many HSCs are observed around sinusoidal blood vessels, and… CONTINUE READING

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