Uncertainty, Neuromodulation, and Attention

@article{Yu2005UncertaintyNA,
  title={Uncertainty, Neuromodulation, and Attention},
  author={A. Yu and P. Dayan},
  journal={Neuron},
  year={2005},
  volume={46},
  pages={681-692}
}
  • A. Yu, P. Dayan
  • Published 2005
  • Medicine, Psychology
  • Neuron
  • Uncertainty in various forms plagues our interactions with the environment. In a Bayesian statistical framework, optimal inference and prediction, based on unreliable observations in changing contexts, require the representation and manipulation of different forms of uncertainty. We propose that the neuromodulators acetylcholine and norepinephrine play a major role in the brain's implementation of these uncertainty computations. Acetylcholine signals expected uncertainty, coming from known… CONTINUE READING
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    References

    SHOWING 1-10 OF 121 REFERENCES
    Expected and Unexpected Uncertainty: ACh and NE in the Neocortex
    • 105
    • PDF
    Acetylcholine in cortical inference
    • 164
    • PDF
    Uncertainty and Learning
    • 97
    Bayesian integration in sensorimotor learning
    • 1,550
    • PDF
    Metalearning and neuromodulation
    • K. Doya
    • Mathematics, Computer Science
    • Neural Networks
    • 2002
    • 576
    • PDF
    Learning by neurones: role of attention, reinforcement and behaviour.
    • S. Sara
    • Biology, Medicine
    • Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie
    • 1998
    • 33
    Inference and computation with population codes.
    • 436
    • PDF
    Neuromodulation: acetylcholine and memory consolidation
    • M. Hasselmo
    • Medicine, Psychology
    • Trends in Cognitive Sciences
    • 1999
    • 703
    • PDF
    Locus coeruleus-evoked responses in behaving rats: A clue to the role of noradrenaline in memory
    • 180