Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: identification of key issues.

@article{Subramaniam2008UncertaintiesIB,
  title={Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: identification of key issues.},
  author={Ravi Subramaniam and Chao Chen and Kenny S. Crump and Danielle Devoney and John F. Fox and Christopher J. Portier and Paul Schlosser and Chad M Thompson and Paul White},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={2008},
  volume={28 4},
  pages={
          907-23
        }
}
In a series of articles and a health-risk assessment report, scientists at the CIIT Hamner Institutes developed a model (CIIT model) for estimating respiratory cancer risk due to inhaled formaldehyde within a conceptual framework incorporating extensive mechanistic information and advanced computational methods at the toxicokinetic and toxicodynamic levels. Several regulatory bodies have utilized predictions from this model; on the other hand, upon detailed evaluation the California EPA has… CONTINUE READING
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Mode of action of liver tumor induc­ tion by trichloroethylene and its metabolites, trichloroac­ etate and dichloroacetate

  • R. J. Bull
  • Environmental Health Perspectives, 108(Suppl 2…
  • 2000
Highly Influential
5 Excerpts

Formaldehyde: Hazard characterization and doseresponse assessment for carcinogenicity by route of inhala­ tion

  • CIIT.
  • Report, Chemical Industry Institute of Toxicology…
  • 1999
Highly Influential
10 Excerpts

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