Uncapping and Deregulation of Telomeres Lead to Detrimental Cellular Consequences in Yeast

@article{Smith1999UncappingAD,
  title={Uncapping and Deregulation of Telomeres Lead to Detrimental Cellular  Consequences in Yeast },
  author={Christopher David Smith and Elizabeth H Blackburn},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={145},
  pages={203 - 214}
}
Telomeres are the protein-nucleic acid structures at the ends of eukaryote chromosomes. Tandem repeats of telomeric DNA are templated by the RNA component (TER1) of the ribonucleoprotein telomerase. These repeats are bound by telomere binding proteins, which are thought to interact with other factors to create a higher-order cap complex that stabilizes the chromosome end. In the budding yeast Kluyveromyces lactis, the incorporation of certain mutant DNA sequences into telomeres leads to… CONTINUE READING

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