Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.

@article{Zhou2007Unc51likeK1,
  title={Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.},
  author={Xiang Zhou and Jeganathan Ramesh Babu and Susana da Silva and Qing Shu and Isabella A. Graef and Tim Oliver and Toshifumi Tomoda and Tomomi Tani and Michael Wooten and Fan Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 14},
  pages={5842-7}
}
The molecular mechanism and significance of endocytic processes involved in directional axon elongation are not well understood. The Unc-51 family of serine/threonine kinases was shown to be important for axon growth and was also linked to endocytosis, providing an entry point to study this problem. We found that mouse Unc-51-like kinase 1/2 (Ulk1/2) proteins are localized to vesicular structures in growth cones of mouse spinal sensory neurons. RNAi-mediated knockdown of Ulk1 and/or Ulk2… CONTINUE READING
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