Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid.

Abstract

The objective of the present study was to examine the accuracy of using unbound brain concentration determined by a brain homogenate method (C(ub)), cerebral spinal fluid concentration (C(CSF)), and unbound plasma concentration (C(up)) as a surrogate for brain interstitial fluid concentration determined by brain microdialysis (C(m)). Nine compounds… (More)
DOI: 10.1124/dmd.108.024125

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Cite this paper

@article{Liu2009UnboundDC, title={Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid.}, author={Xingrong Liu and Kristine Van Natta and H. C. H. Yeo and Olga Vilenski and Paul E Weller and Philip D. Worboys and Mario Monshouwer}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2009}, volume={37 4}, pages={787-93} }