Unblinding of trial participants to their treatment allocation: lessons from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)

@article{Dinnett2005UnblindingOT,
  title={Unblinding of trial participants to their treatment allocation: lessons from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)},
  author={E. Dinnett and M. M. Mungall and J. Kent and Elizabeth S Ronald and K. McIntyre and Elizabeth Anderson and A. Gaw},
  journal={Clinical Trials},
  year={2005},
  volume={2},
  pages={254 - 259}
}
Background The gold standard clinical trial design is the double-blind, randomized, controlled trial. No standard practice exists for the “unblinding” of trial participants and no legal obligation is placed on investigators to inform participants of their treatment allocation or study results at the end of a trial. Here we document our experiences of unblinding the 2520 Scottish participants in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Methods The objectives of the… Expand
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References

SHOWING 1-10 OF 13 REFERENCES
Informing participants of allocation to placebo at trial closure: postal survey
A Prospective Study of Pravastatin in the Elderly at Risk (PROSPER): Screening Experience and Baseline Characteristics
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
Blinding in randomised trials: hiding who got what
Clinical Trials Registry
  • S. Cook
  • Medicine
  • New Jersey medicine : the journal of the Medical Society of New Jersey
  • 2005
...
1
2
...