Unbiased estimation of odds ratios: combining genomewide association scans with replication studies

Abstract

Odds ratios or other effect sizes estimated from genome scans are upwardly biased, because only the top-ranking associations are reported, and moreover only if they reach a defined level of significance. No unbiased estimate exists based on data selected in this fashion, but replication studies are routinely performed that allow unbiased estimation of the… (More)
DOI: 10.1002/gepi.20394

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