Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells

Abstract

Forward genetic screens in haploid mammalian cells have recently emerged as powerful tools for the discovery and investigation of recessive traits. Use of the haploid system provides unique genetic tractability and resolution. Upon positive selection, these screens typically employ analysis of loss-of-function (LOF) alleles and are thus limited to non… (More)
DOI: 10.18632/oncotarget.24305

Topics

4 Figures and Tables