Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

  title={Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing},
  author={Dmitry Usoskin and Alessandro Furlan and Saiful Islam and Hind Abdo and Peter L{\"o}nnerberg and Daohua Lou and Jens Hjerling-Leffler and Jesper Z. Haeggstr{\"o}m and Olga A. Kharchenko and Peter V. Kharchenko and Sten Linnarsson and Patrik Ernfors},
  journal={Nature Neuroscience},
The primary sensory system requires the integrated function of multiple cell types, although its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 single mouse neurons to classify them in an unbiased manner, independent of any a priori knowledge of sensory subtypes. Our results reveal eleven types: three distinct low-threshold mechanoreceptive neurons, two proprioceptive, and six principal types of thermosensitive, itch sensitive, type C low-threshold… 

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