Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis

@inproceedings{Alvarez2019UnbiasedAO,
  title={Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis},
  author={Mariano J. Alvarez and Pengrong Yan and Mary L Alpaugh and Michaela Bowden and Ewa Sicińska and Chensheng Willa Zhou and Charles Karan and Ronald Realubit and Prabhjot S. Mundi and Adina Grunn and Dirk Jaeger and John Alva Chabot and Antonio Tito Fojo and Paul E Oberstein and Hanina Hibshoosh and Jeffrey w. Milsom and Matthew H. Kulke and Massimo Loda and Gabriela Chiosis and Diane L Reidy-Lagunes and Andrea Califano},
  year={2019}
}
  • Mariano J. Alvarez, Pengrong Yan, +18 authors Andrea Califano
  • Published 2019
  • Biology
  • Quantitative metrics to objectively assess the fidelity of cancer models, such as cell lines, organoids, or patient-derived xenografts (PDXs), remain elusive, with histological criteria or the presence of specific mutations often used as driving principles. We show that molecular criteria, based on the regulatory proteins responsible for maintaining transcriptional cell state and its regulatory network, are effective in identifying models that can recapitulate drug mechanism of action and drug… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv