Unbiased Analysis of TCRα/β Chains at the Single-Cell Level in Human CD8+ T-Cell Subsets

@inproceedings{Sun2012UnbiasedAO,
  title={Unbiased Analysis of TCRα/β Chains at the Single-Cell Level in Human CD8+ T-Cell Subsets},
  author={Xiaoming Sun and Masumichi Saito and Yoshinori Sato and Takayuki Chikata and Takuya Naruto and Tatsuhiko Ozawa and Eiji Kobayashi and Hiroyuki Kishi and Atsushi Muraguchi and Masafumi Takiguchi},
  booktitle={PloS one},
  year={2012}
}
T-cell receptor (TCR) α/β chains are expressed on the surface of CD8(+) T-cells and have been implicated in antigen recognition, activation, and proliferation. However, the methods for characterization of human TCRα/β chains have not been well established largely because of the complexity of their structures owing to the extensive genetic rearrangements that they undergo. Here we report the development of an integrated 5'-RACE and multiplex PCR method to amplify the full-length transcripts of… CONTINUE READING
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