Unbalanced activation of ERK1/2 and MEK1/2 in apigenin-induced HeLa cell death.

@article{Llorens2004UnbalancedAO,
  title={Unbalanced activation of ERK1/2 and MEK1/2 in apigenin-induced HeLa cell death.},
  author={Franc Llorens and Francesc A Mir{\'o} and Arnau Casa{\~n}as and Nerea Roher and Lourdes Garc{\'i}a Garc{\'i}a and Maria Plana and Nestor Gomez and Emilio Itarte},
  journal={Experimental cell research},
  year={2004},
  volume={299 1},
  pages={15-26}
}
Apigenin, a dietary bioflavonoid with anticarcinogenic properties, was highly cytotoxic for HeLa cells (incubated with 0.5% FBS). This effect was accompanied with a marked increase in ERK1/2 but not MEK1/2 phosphorylation. The cytotoxic effects of apigenin were attenuated by the stimulation of these cells with 10% FBS, which provoked an increase in the phosphorylation levels of MEK1/2 and ERK1/2. The steps in the ERK1/2 pathway relevant to the cytotoxic effects of apigenin, as well as the… CONTINUE READING

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