Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate

@inproceedings{Tyler2012UnassembledCI,
  title={Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate},
  author={Ryan E. Tyler and Margaret M. P. Pearce and Thomas A. Shaler and James A Olzmann and Ethan J Greenblatt and Ron R. Kopito},
  booktitle={Molecular biology of the cell},
  year={2012}
}
Degradation of folding- or assembly-defective proteins by the endoplasmic reticulum-associated degradation (ERAD) ubiquitin ligase, Hrd1, is facilitated by a process that involves recognition of demannosylated N-glycans by the lectin OS-9/XTP3-B via the adaptor protein SEL1L. Most of our knowledge of the machinery that commits proteins to this fate in metazoans comes from studies of overexpressed mutant proteins in heterologous cells. In this study, we used mass spectrometry to identify core… CONTINUE READING

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SEL 1 L nucleates a protein complex required for dislocation of misfolded glycoproteins

  • B Mueller, EJ Klemm, E Spooner, JH Claessen, HL Ploegh
  • Mol Biol Cell
  • 2008
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