Unaltered expression of multidrug resistance transporters in polycyclic aromatic hydrocarbon-resistant rat liver cells.

@article{Payen2001UnalteredEO,
  title={Unaltered expression of multidrug resistance transporters in polycyclic aromatic hydrocarbon-resistant rat liver cells.},
  author={L. A. Payen and Arnaud Courtois and Sophie A Langou{\"e}t and Andr{\'e} Guillouzo and Olivier Fardel},
  journal={Toxicology},
  year={2001},
  volume={156 2-3},
  pages={109-17}
}
Rat liver epithelial cells resistant to the chemical carcinogen 3MC, termed F258/3MC cells and generated by long-term exposure of parental F258 cells to the PAH, were characterized, especially with respect to expression of multidrug resistance transporters such as P-glycoprotein, MRP1 and MRP2. F258/3MC cells were found to be cross-resistant to other PAHs such as BP and dimethylbenz(a)anthracene but remained sensitive to known substrates of multidrug resistance efflux pumps such as doxorubicin… CONTINUE READING