Unaffected motor endplate occupancy in eye muscles of ALS G93A mouse model.

@article{Tjust2012UnaffectedME,
  title={Unaffected motor endplate occupancy in eye muscles of ALS G93A mouse model.},
  author={Anton E Tjust and Thomas Brannstrom and Fatima Pedrosa Domellof},
  journal={Frontiers in bioscience},
  year={2012},
  volume={4},
  pages={1547-55}
}
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disorder characterised by selective loss of motor neurons with accompanying muscle paralysis and respiratory failure. Despite progressive paralysis in trunk and extremity muscles, disturbed eye motility is not a hallmark of ALS. Extraocular muscles (EOMs) of terminal ALS patients show far less morphological signs of disease than their limb muscles. One of the earliest signs of the disease in the transgenic G93A SOD1… CONTINUE READING