Umbilical cord stem cells released from alginate-fibrin microbeads inside macroporous and biofunctionalized calcium phosphate cement for bone regeneration.

@article{Chen2012UmbilicalCS,
  title={Umbilical cord stem cells released from alginate-fibrin microbeads inside macroporous and biofunctionalized calcium phosphate cement for bone regeneration.},
  author={Wenchuan Chen and Hongzhi Zhou and Michael David Weir and Chongyun Bao and Hockin H K Xu},
  journal={Acta biomaterialia},
  year={2012},
  volume={8 6},
  pages={
          2297-306
        }
}
The need for bone repair has increased as the population ages. The objectives of this study were to (1) develop a novel biofunctionalized and macroporous calcium phosphate cement (CPC) containing alginate-fibrin microbeads encapsulating human umbilical cord mesenchymal stem cells (hUCMSC) and, for the first time, (2) investigate hUCMSC proliferation and osteogenic differentiation inside the CPC. A macroporous CPC was developed using calcium phosphate powder, chitosan, and a gas-foaming porogen… CONTINUE READING
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