Umbilical cord mesenchymal stem cells suppress host rejection: the role of the glycocalyx.

@article{CoulsonThomas2014UmbilicalCM,
  title={Umbilical cord mesenchymal stem cells suppress host rejection: the role of the glycocalyx.},
  author={Vivien J Coulson-Thomas and Tarsis Ferreira Gesteira and Vincent C. Hascall and Winston W. Y. Kao},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 34},
  pages={23465-81}
}
Umbilical cord mesenchymal stem cells (UMSCs) have unique immunosuppressive properties enabling them to evade host rejection and making them valuable tools for cell therapy. We previously showed that human UMSCs survive xenograft transplantation and successfully correct the corneal clouding defects associated with the mouse model for the congenital metabolic disorder mucopolysaccharidosis VII. However, the precise mechanism by which UMSCs suppress the immune system remains elusive. This study… CONTINUE READING

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Moreover , UMSCs exposed to inflammatory cells synthesize a rich extracellular glycocalyx composed of the chondroitin sulfate - proteoglycan versican bound to a heavy chain ( HC)-modified hyaluronan ( HA ) matrix ( HC - HA ) .
Moreover , UMSCs exposed to inflammatory cells synthesize a rich extracellular glycocalyx composed of the chondroitin sulfate - proteoglycan versican bound to a heavy chain ( HC)-modified hyaluronan ( HA ) matrix ( HC - HA ) .
We previously showed that human UMSCs survive xenograft transplantation and successfully correct the corneal clouding defects associated with the mouse model for the congenital metabolic disorder mucopolysaccharidosis VII .
We previously showed that human UMSCs survive xenograft transplantation and successfully correct the corneal clouding defects associated with the mouse model for the congenital metabolic disorder mucopolysaccharidosis VII .
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