Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn1−/− mice

@article{Liu2014UmbilicalCM,
  title={Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn1−/− mice},
  author={Guangyang Liu and Lihua Wang and Tian-xiang Pang and Delin Zhu and Yi Xu and Hanyu Wang and Xiuli Cong and Yongjun Liu},
  journal={Cellular and Molecular Immunology},
  year={2014},
  volume={11},
  pages={275-284}
}
Thymic microenvironments are essential for the maturation of thymocytes, which can be anatomically compartmentalized into cortical and medullar regions. The absence of the gene encoding the transcription factor forkhead box n1 (Foxn1) causes epithelial differentiation to stall in the precursor stage, resulting in the formation of an abnormal thymus. In this study, we used human umbilical cord-derived mesenchymal stem cells (UC-MSCs) to treat Foxn1−/− mice, and then analyzed the maturation and… CONTINUE READING

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