Umbilical cord blood-derived CD34⁺ cells improve outcomes of traumatic brain injury in rats by stimulating angiogenesis and neurogenesis.

@article{Chen2014UmbilicalCB,
  title={Umbilical cord blood-derived CD34⁺ cells improve outcomes of traumatic brain injury in rats by stimulating angiogenesis and neurogenesis.},
  author={Sheng-Hsien Chen and Jhi-Joung Wang and Chung-Hwan Chen and Hsiu-Kang Chang and M. -T. Lin and Fong-Ming Chang and Chung-Ching Chio},
  journal={Cell transplantation},
  year={2014},
  volume={23 8},
  pages={959-79}
}
Human umbilical cord blood cells (HUCBCs) have been shown to be beneficial in reducing neurological deficits in rats with brain fluid percussion injury (FPI). This study aimed to assess the basic mechanisms underlying the neuroprotective effects of HUCBC-derived cluster of differentiation 34-positive (CD34⁺) cells. Rats were divided into three major groups: (i) sham-operated controls; (ii) FPI rats treated with phosphate-buffered saline (PBS); (iii) FPI rats treated with 0.2%, 50%, or 95% CD34… CONTINUE READING
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