Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull mice

@inproceedings{Evert2017UmbilicalCB,
  title={Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull mice},
  author={Janneke S. Hoogstad-van Evert and Jeannette Cany and Dirk van den Brand and Manon Oudenampsen and Roland E Brock and Ruurd Torensma and Ruud L. M. Bekkers and Joop Jansen and Leon Fag Massuger and Harry Dolstra},
  booktitle={Oncoimmunology},
  year={2017}
}
Adoptive transfer of allogeneic natural killer (NK) cells is an attractive therapy approach against ovarian carcinoma. Here, we evaluated the potency of highly active NK cells derived from human CD34+ haematopoietic stem and progenitor cells (HSPC) to infiltrate and mediate killing of human ovarian cancer spheroids using an in vivo-like model system and mouse xenograft model. These CD56+Perforin+ HSPC-NK cells were generated under stroma-free conditions in the presence of StemRegenin-1, IL-15… CONTINUE READING
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