Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cell. I. Chemical modifications of ultraviolet-treated low-density lipoproteins.

@article{Dousset1990UltraviolettreatedLA,
  title={Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cell. I. Chemical modifications of ultraviolet-treated low-density lipoproteins.},
  author={Nicole Dousset and Anne N{\`e}gre-Salvayre and M L{\'o}pez and Robert Salvayre and Louis Douste-Blazy},
  journal={Biochimica et biophysica acta},
  year={1990},
  volume={1045 3},
  pages={
          219-23
        }
}
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64 Citations
Background Citations
2
Methods Citations
6
Results Citations
1

64 Citations

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways.

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines.

UV-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. 4. Calcium is involved in the cytotoxicity of UV-treated LDL on lymphoid cell lines.

Fluorescence analysis of lipoprotein peroxidation.

Subcellular Alterations Induced by UV-Oxidized Low-Density Lipoproteins in Epithelial Cells Can Be Counteracted by α-Tocopherol

The results presented here could be of relevance for a better comprehension of the pathogenic mechanisms of several human diseases, including dermatological pathologies, and could indicate that antioxidants such as α-tocopherol could represent an important therapeutic challenge in the maintenance of cell and tissue homeostasis in the long run.

α-tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells

The inhibition of the oxidation of low density lipoprotein by (+)-catechin, a naturally occurring flavonoid.

Oxidized Low Density Lipoprotein Reduces Thrombomodulin Transcription in Cultured Human Endothelial Cells through Degradation of the Lipoprotein in Lysosomes (*)

Results suggested that down-regulation of TM on endothelial cells exposed to oxidized LDL resulted from inhibition of its transcription mediated by lysosomal degradation of oxidization LDL and that a lipid component in the LDL could be an active species.

Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cell lines.

Subcellular Alterations Induced by UV‐Oxidized Low‐Density Lipoproteins in Epithelial Cells Can Be Counteracted by α‐Tocopherol

The results presented here could be of relevance for a better comprehension of the pathogenic mechanisms of several human diseases, including dermatological pathologies, and could indicate that antioxidants such as α‐tocopherol could represent an important therapeutic challenge in the maintenance of cell and tissue homeostasis in the long run.
...

References

SHOWING 1-10 OF 34 REFERENCES

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines.

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification.

It is shown that incubation of LDL with purified soybean lipoxygenase, in the presence of pure phospholipase A2, can mimic endothelial cell-induced oxidative modification, and represents the first example of oxidative modification of LDL by specific enzymes leading to enhanced recognition by macrophages.

Studies on oxidized low density lipoproteins. Controlled oxidation and a prostaglandin artifact.

Low density lipoproteins (LDL), isolated by ultracentrifugal flotation, were oxidized slowly during dialysis against 0.15 M NaCl and subsequent incubation in 96% air-4% CO2 at 37 degrees C and cross-reacting material in LDLOXID preparations was evidently formed from the oxidation of free fatty acids released from LDL.

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes.

The rate and extent of the change of LDL constituents occurring during lipid peroxidation is reported for the first time, and 4-hydroxynonenal was most effective, followed by 2,4-heptadienal, hexanal, and malonaldehyde.

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

Macrophage Oxidation of Low Density Lipoprotein Generates a Modified Form Recognized by the Scavenger Receptor

The degradation of 125l-labeled macrophage-modified LDL by macrophages was competitively inhibited by unlabeled acetyl LDL or unlabeling endothelial cell-modified HDL but not by native LDL, indicating that the degradation was mediated by the acetyl HDL receptor.

Spectrophotometric detection of lipid conjugated dienes.

Changes in the secondary structure of apolipoprotein B-100 after Cu2+-catalysed oxidation of human low-density lipoproteins monitored by Fourier transform infrared spectroscopy.

The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages.

It is possible that the site that binds negatively-charged LDL may be responsible for the massive accumulation of cholesteryl esters that occurs in vivo in macrophages and other scavenger cells in patients with high levels of circulating plasma LDL.

Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100.