Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cell. I. Chemical modifications of ultraviolet-treated low-density lipoproteins.
@article{Dousset1990UltraviolettreatedLA, title={Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cell. I. Chemical modifications of ultraviolet-treated low-density lipoproteins.}, author={Nicole Dousset and Anne N{\`e}gre-Salvayre and M L{\'o}pez and Robert Salvayre and Louis Douste‐Blazy}, journal={Biochimica et biophysica acta}, year={1990}, volume={1045 3}, pages={ 219-23 } }
64 Citations
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways.
- Biology, ChemistryBiochimica et biophysica acta
- 1991
UV-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. 4. Calcium is involved in the cytotoxicity of UV-treated LDL on lymphoid cell lines.
- BiologyBiochimica et biophysica acta
- 1992
WAVELENGTH DEPENDENCE OF PHOTOINDUCED PEROXIDATION AND CYTOTOXICITY OF HUMAN LOW DENSITY LIPOPROTEINS
- Chemistry, BiologyPhotochemistry and photobiology
- 1992
Under all the conditions used, apoB was not affected by the UV radiations as shown by the stability of amino acid composition and of trinitrobenzenesulfonic acid reactive amino group content, and the low density lipoprotein size was not altered.
Subcellular Alterations Induced by UV-Oxidized Low-Density Lipoproteins in Epithelial Cells Can Be Counteracted by α-Tocopherol
- BiologyPhotochemistry and photobiology
- 2000
The results presented here could be of relevance for a better comprehension of the pathogenic mechanisms of several human diseases, including dermatological pathologies, and could indicate that antioxidants such as α-tocopherol could represent an important therapeutic challenge in the maintenance of cell and tissue homeostasis in the long run.
Recycling of vitamin E in human low density lipoproteins.
- BiologyJournal of lipid research
- 1992
It is suggested that the recycling of vitamin E and other phenolic antioxidants by plasma reductants may be an important mechanism for the enhanced antioxidant protection of LDL.
In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals.
- Biology, ChemistryThe Journal of clinical investigation
- 1995
Cell death was postulated to occur due to lipid peroxidation via a sequence involving lipid hydroperoxide-induced, iron-mediated formation of alkoxyl, lipid, and peroxyl radicals, consistent with current theories linking lipoprotein oxidation to atherosclerosis.
The inhibition of the oxidation of low density lipoprotein by (+)-catechin, a naturally occurring flavonoid.
- Biology, ChemistryBiochemical pharmacology
- 1992
Oxidized Low Density Lipoprotein Reduces Thrombomodulin Transcription in Cultured Human Endothelial Cells through Degradation of the Lipoprotein in Lysosomes (*)
- BiologyThe Journal of Biological Chemistry
- 1996
Results suggested that down-regulation of TM on endothelial cells exposed to oxidized LDL resulted from inhibition of its transcription mediated by lysosomal degradation of oxidization LDL and that a lipid component in the LDL could be an active species.
Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cell lines.
- BiologyFree radical biology & medicine
- 1992
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