Ultraviolet radiation induces p16CDKN2A expression in human skin.

  title={Ultraviolet radiation induces p16CDKN2A expression in human skin.},
  author={S Pavey and S Conroy and T Russell and Brian G Gabrielli},
  journal={Cancer research},
  volume={59 17},
The loss of the tumor suppressor gene product p16 in melanoma is well documented, although the normal physiological function of p16 in skin melanocytes is unknown. In this report, we demonstrate that when human skin was irradiated with suberythemal doses of UV radiation, levels of p16 were dramatically increased by 16 h postirradiation, peaking at 24 h, and declining by 72 h. p16 was expressed in the nucleus and cytoplasm of melanocytes and keratinocytes within the epidermis, and the pattern of… CONTINUE READING
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Cyclin D-Cdk4 activity required for G 2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G 2 phase delay

  • B. F. Gabrelli, B. Sarcevic, +5 authors K. A. Ellem
  • J. Biol
  • 1999
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