Ultraviolet mutagenesis and the SOS response in Escherichia coli: a personal perspective.

@article{Witkin1989UltravioletMA,
  title={Ultraviolet mutagenesis and the SOS response in Escherichia coli: a personal perspective.},
  author={Evelyn M. Witkin},
  journal={Environmental and molecular mutagenesis},
  year={1989},
  volume={14 Suppl 16},
  pages={30-4}
}
The study of ultraviolet (UV) mutagenesis in Escherichia coli began with the assumption that genes were likely to be changed at the instant of photon absorption. Over many decades, it became clear that postirradiation cellular activities, including enzymatic DNA repair of UV photo products and error-prone modes of tolerating unrepaired DNA lesions can exert profound influences on the mutagenic outcome of irradiation. Current study focusses on the molecular details of radiation-induced… CONTINUE READING

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