Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum.

@article{Wu2002UltravioletLI,
  title={Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum.},
  author={Shiyong Wu and Yuanyuan Hu and Ju-Lin Wang and Madhumita Chatterjee and Yuguang Shi and Randal J Kaufman},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 20},
  pages={18077-83}
}
Exposure to ultraviolet light can cause inflammation, premature skin aging, and cancer. UV irradiation alters the expression of multiple genes that encode functions to repair DNA damage, arrest cell growth, and induce apoptosis. In addition, UV irradiation inhibits protein synthesis, although the mechanism is not known. In this report, we show that UV irradiation induces phosphorylation of eukaryotic translation initiation factor 2 on the alpha-subunit (eIF2alpha) and inhibits protein synthesis… CONTINUE READING
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