Ultraviolet light induces the sustained unscheduled expression of cyclin E in the absence of functional p53.

@article{Stubbert2009UltravioletLI,
  title={Ultraviolet light induces the sustained unscheduled expression of cyclin E in the absence of functional p53.},
  author={Lawton J Stubbert and Jennifer C Spronck and Jeff D. Hamill and Bruce C McKay},
  journal={Cell cycle},
  year={2009},
  volume={8 18},
  pages={2995-3002}
}
Cell cycle progression is regulated through changes in the activity of cyclin-dependent kinases that are, in turn, regulated by the expression of their respective cyclin partners. In primary cells, cyclin E expression increases through the G(1) phase of the cell cycle and peaks near the G(1)/S boundary. The unscheduled expression of cyclin E in primary human fibroblasts leads to chromosomal instability that is greatly increased by loss of the p53 tumour suppressor. Intriguingly, ultraviolet… CONTINUE READING