Ultraviolet light-induced DNA repair synthesis in hepatocytes from species of differing longevities
@article{Maslansky1985UltravioletLD, title={Ultraviolet light-induced DNA repair synthesis in hepatocytes from species of differing longevities}, author={Carol J. Maslansky and Gary M Williams}, journal={Mechanisms of Ageing and Development}, year={1985}, volume={29}, pages={191-203} }
23 Citations
The hepatocyte primary culture/DNA repair test using hepatocytes from several species
- Biology, MedicineCell Biology and Toxicology
- 2004
Examples are discussed that illustrate that the genotoxicity of a chemical can be a species-specific response and that multi-species testing permits a more complete assessment of genot toxicity.
Effects of carcinogen treatment on rat liver DNA synthesis in vivo and on nascent DNA synthesis and elongation in cultured hepatocytes.
- Biology, MedicineMutation research
- 1986
Influence of age, sex and strain on the in vitro induction of unscheduled dna synthesis in rat hepatocyte primary cultures
- Biology, MedicineCell Biology and Toxicology
- 2004
The most striking finding was the absence of a UDS response to 2-acetylaminofuorene by hepatocytes from Sprague-Dawley females at the 8, 14, 20 or 25 month periods.
Effect of nalidixic acid on DNA repair in rat hepatocytes
- Biology, MedicineCell Biology and Toxicology
- 2004
Results indicate that nalidixic acid does not damage DNA or inhibit DNA repair processes in hepatocytes.
DNA repair by articular chondrocytes. III. Unscheduled DNA synthesis following ultraviolet light irradiation of resting cartilage
- Medicine, BiologyMechanisms of Ageing and Development
- 1985
Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and Toxicity
- BiologyToxicologic pathology
- 2002
At all levels of organization, adaptive responses are beneficial in that they enhance the capacity of all units to respond to chemical induced stress, are reversible and preserve viability.
Effects of aging and caloric restriction on the genotoxicity of four carcinogens in the in vitro rat hepatocyte/DNA repair assay.
- BiologyMutation research
- 1993
Liver cell culture methods to measure DNA alterations produced by chemicals and radiation
- BiologyCell Biology and Toxicology
- 2004
Liver culture systems, both primary cultures of hepatocytes and replicating cell lines, can be used in a variety of ways to study the DNA-damaging effects of chemicals and radiation. The present…
Liver cell culture methods for measuring DNA alterations produced by chemicals and radiation
- BiologyCell Biology and Toxicology
- 2004
Liver culture systems, both primary cultures of hepatocytes and replicating cell lines, can be used in a variety of ways to study the DNA-damaging effects of chemicals and radiation. The present…
DNA — Information and Aging: The Balance Between Alteration and Repair
- Biology
- 1989
Kirkwood and Holliday (1979) have suggested that a lower level of accuracy in synthesis and repair of macromolecules in somatic cells is (as compared with germ cells) an adaptation which saves energy; they postulate that aging occurs as a consequence.
References
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There was no correlation between repair potentials and life span, denying the presence of the correlation suggested by Hart and Setlow on 7 species.
Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span
- Biology, MedicineMechanisms of Ageing and Development
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Correlation between DNA excision repair and mammalian lifespan in lens epithelial cells.
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DNA repair synthesis in rat retinal ganglion cells treated with chemical carcinogens or ultraviolet light in vitro, with special reference to aging and repair level.
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A system in which the retinal tissues of noninbred Wistar rats were used in combination with autoradiography was developed for measurement of DNA repair synthesis in ganglion cells of the central…
Age-related decrease of ultraviolet light-induced DNA repair synthesis in human peripheral leukocytes.
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The capacity for ultraviolet light-induced DNA repair synthesis, studied in peripheral leukocytes from 58 healthy subjects 13 to 94 years old, was found to vary greatly between individuals, indicating a decrease in repair capacity with age.
DNA repair response in human epidermal keratinocytes from donors of different age.
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No significant age-related differences exist in the rate and extent of the repair-replication response of human epidermal keratinocytes to UV-radiation damage in DNA, but it remains to be determined whether other cellular recovery responses to damaged DNA are also relatively unrelated to age.
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Changing capacity for DNA excision repair in mouse embryonic cells in vitro.
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Inhibition of DNA repair in ultraviolet-irradiated human cells by hydroxyurea.
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