Ultraviolet light-induced DNA repair synthesis in hepatocytes from species of differing longevities

@article{Maslansky1985UltravioletLD,
  title={Ultraviolet light-induced DNA repair synthesis in hepatocytes from species of differing longevities},
  author={Carol J. Maslansky and Gary M Williams},
  journal={Mechanisms of Ageing and Development},
  year={1985},
  volume={29},
  pages={191-203}
}
The hepatocyte primary culture/DNA repair test using hepatocytes from several species
TLDR
Examples are discussed that illustrate that the genotoxicity of a chemical can be a species-specific response and that multi-species testing permits a more complete assessment of genot toxicity.
Influence of age, sex and strain on the in vitro induction of unscheduled dna synthesis in rat hepatocyte primary cultures
TLDR
The most striking finding was the absence of a UDS response to 2-acetylaminofuorene by hepatocytes from Sprague-Dawley females at the 8, 14, 20 or 25 month periods.
Effect of nalidixic acid on DNA repair in rat hepatocytes
TLDR
Results indicate that nalidixic acid does not damage DNA or inhibit DNA repair processes in hepatocytes.
Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and Toxicity
TLDR
At all levels of organization, adaptive responses are beneficial in that they enhance the capacity of all units to respond to chemical induced stress, are reversible and preserve viability.
Liver cell culture methods to measure DNA alterations produced by chemicals and radiation
Liver culture systems, both primary cultures of hepatocytes and replicating cell lines, can be used in a variety of ways to study the DNA-damaging effects of chemicals and radiation. The present
Liver cell culture methods for measuring DNA alterations produced by chemicals and radiation
Liver culture systems, both primary cultures of hepatocytes and replicating cell lines, can be used in a variety of ways to study the DNA-damaging effects of chemicals and radiation. The present
DNA — Information and Aging: The Balance Between Alteration and Repair
TLDR
Kirkwood and Holliday (1979) have suggested that a lower level of accuracy in synthesis and repair of macromolecules in somatic cells is (as compared with germ cells) an adaptation which saves energy; they postulate that aging occurs as a consequence.
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References

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ABSENCE OF CORRELATION BETWEEN DNA REPAIR IN ULTRAVIOLET IRRADIATED MAMMALIAN CELLS AND LIFE SPAN OF THE DONOR SPECIES
TLDR
There was no correlation between repair potentials and life span, denying the presence of the correlation suggested by Hart and Setlow on 7 species.
DNA repair synthesis in rat retinal ganglion cells treated with chemical carcinogens or ultraviolet light in vitro, with special reference to aging and repair level.
A system in which the retinal tissues of noninbred Wistar rats were used in combination with autoradiography was developed for measurement of DNA repair synthesis in ganglion cells of the central
Age-related decrease of ultraviolet light-induced DNA repair synthesis in human peripheral leukocytes.
TLDR
The capacity for ultraviolet light-induced DNA repair synthesis, studied in peripheral leukocytes from 58 healthy subjects 13 to 94 years old, was found to vary greatly between individuals, indicating a decrease in repair capacity with age.
DNA repair response in human epidermal keratinocytes from donors of different age.
TLDR
No significant age-related differences exist in the rate and extent of the repair-replication response of human epidermal keratinocytes to UV-radiation damage in DNA, but it remains to be determined whether other cellular recovery responses to damaged DNA are also relatively unrelated to age.
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