Ultraviolet laser-induced cross-linking in peptides.

@article{Leo2013UltravioletLC,
  title={Ultraviolet laser-induced cross-linking in peptides.},
  author={Gabriella Leo and Carlo Altucci and Sandrine Bourgoin-Voillard and Alfredo Maria Gravagnuolo and Rosario Esposito and Gennaro Marino and Catherine E. Costello and Raffaele Velotta and Leila Birolo},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2013},
  volume={27 14},
  pages={
          1660-8
        }
}
RATIONALE The aim of this study was to demonstrate, and to characterize by high-resolution mass spectrometry that it is possible to preferentially induce covalent cross-links in peptides by using high-energy femtosecond ultraviolet (UV) laser pulses. The cross-link is readily formed only when aromatic amino acids are present in the peptide sequence. METHODS Three peptides, xenopsin, angiotensin I, and interleukin, individually or in combination, were exposed to high-energy femtosecond UV… CONTINUE READING
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