Ultraviolet irradiation transforms C3H10T1/2 cells to a unique, suppressible phenotype.

@article{Herschman1986UltravioletIT,
  title={Ultraviolet irradiation transforms C3H10T1/2 cells to a unique, suppressible phenotype.},
  author={Harvey R. Herschman and David W. Brankow},
  journal={Science},
  year={1986},
  volume={234 4782},
  pages={
          1385-8
        }
}
Transformation of C3H10T1/2 cells by exposure to ultraviolet (UV) irradiation followed by tetradecanoyl phorbol acetate (TPA) has been used as a model of two-stage carcinogenesis. However, cells cloned from UV-TPA-induced foci (UV-TDTx cells) had a unique phenotype. Cloned UV-TDTx cells appeared transformed in pure culture but were unable to form foci when cocultured with C3H10T1/2 cells. However, in the presence of TPA, UV-TDTx cells form foci in mixed culture with C3H10T1/2 cells. This… CONTINUE READING
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