Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear translocation in human keratinocytes.

@article{Xu2009UltravioletIE,
  title={Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear translocation in human keratinocytes.},
  author={Yiru Xu and Yuan Pu Shao and Jin Zhou and John J. Voorhees and Gary J. Fisher},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={107 5},
  pages={873-80}
}
Epidermal growth factor receptor (EGFR) plays a critical role in mediating ultraviolet (UV) irradiation-induced signal transduction and gene expression in human keratinocytes. EGFR activation results from increased phosphorylation on specific tyrosine residues in the C-terminal intracellular domain. It has recently been reported that following growth factor stimulation EGFR translocates from the surface membrane to the nucleus, where it may directly regulate gene transcription. We have… CONTINUE READING

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