Ultraviolet-induced p53 mutations in atypical fibroxanthoma.

  title={Ultraviolet-induced p53 mutations in atypical fibroxanthoma.},
  author={Angelo P Dei Tos and Roberta Maestro and Claudio Doglioni and Daniela Gasparotto and Mauro Boiocchi and Licia Laurino and Christopher D. M. Fletcher},
  journal={The American journal of pathology},
  volume={145 1},
Atypical fibroxanthoma (AFX) is an uncommon neoplasm of the superficial soft tissue occurring in actinically damaged skin of elderly patients. Sun-exposed skin also represents the main site of squamous and basal cell carcinomas and malignant melanoma, and a key role for ultraviolet (UV) radiation in their pathogenesis has long been suspected. UV-related mutations of the p53 gene have been identified in human skin cancers. To verify whether the pathogenesis of AFX is related to the effect of… CONTINUE READING
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