Ultraviolet filter compounds in human lenses: 3-hydroxykynurenine glucoside formation

@article{Wood1994UltravioletFC,
  title={Ultraviolet filter compounds in human lenses: 3-hydroxykynurenine glucoside formation},
  author={A. Michelle Wood and Roger John Willis Truscott},
  journal={Vision Research},
  year={1994},
  volume={34},
  pages={1369-1374}
}
Experiments have been conducted on various aspects of the biosynthetic pathway leading to the formation of 3-hydroxykynurenine glucoside (3OHKG), the major tryptophan-derived human lens UV filter compound. Measurable levels of the reactive metabolite, 3-hydroxykynurenine (3OHKyn) were found in normal human lenses, including lens nuclei. 3OHKyn was able to enter organ-cultured lenses and to serve as a substrate for production of 3OHKG. Thus lenticular 3OKHyn can potentially be derived either by… CONTINUE READING

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