Ultraviolet Radiation Induction of Squamous Cell Carcinomas in p 53 Transgenic Mice 1

@inproceedings{Li2006UltravioletRI,
  title={Ultraviolet Radiation Induction of Squamous Cell Carcinomas in p 53 Transgenic Mice 1},
  author={Gang Li and Vincent C. Ho and Ken W Berean and Victor A. Tron},
  year={2006}
}
Mutations of the p53 gene have been implicated in the pathogenesis of cutaneous squamous cell carcinoma (SCC). To examine the role ol'/o.f in skin carcinogenesis, we observed the development of skin cancers in p53 transgenic mice which carry multiple copies of a mutant alÃ-eleof the p53 gene with or without chronic UVB radiation. Thirty-one tumors developed in 19 UV-irradiated p53 transgenic mice versus 14 of 19 in the control group; 9 p53 transgenic mice but none of the control mice developed… CONTINUE READING