Ultraviolet B wavelength dependence for the regulation of two major matrix-metalloproteinases and their inhibitor TIMP-1 in human dermal fibroblasts.

@article{Brenneisen1996UltravioletBW,
  title={Ultraviolet B wavelength dependence for the regulation of two major matrix-metalloproteinases and their inhibitor TIMP-1 in human dermal fibroblasts.},
  author={Peter Brenneisen and J Oh and Meinhard Wlaschek and Jutta Wenk and Karlis Briviba and Christina Hommel and Gernot Herrmann and Helmut Sies and Karin Scharffetter-Kochanek},
  journal={Photochemistry and photobiology},
  year={1996},
  volume={64 5},
  pages={877-85}
}
The wavelength dependence for the regulation of two major matrix-metalloproteinases, interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3), and their major inhibitor, tissue inhibitor of metalloproteinases (TIMP-1), was studied in human dermal fibroblasts in vitro. Monochromatic irradiation at 302, 307, 312 and 317 nm with intensities ranging from 20 to 300 J/m2 increased MMP-1 and MMP-3 mRNA steady-state levels and the secretion of the corresponding proteins up to 4.4-fold, whereas almost… CONTINUE READING