Ultraviolet B radiation illuminates the role of TLR3 in the epidermis

  title={Ultraviolet B radiation illuminates the role of TLR3 in the epidermis},
  author={Andrew W. Borkowski and Richard L Gallo},
  booktitle={The Journal of investigative dermatology},
UV radiation poses a significant risk to human health. The mechanisms that help repair UV-damaged cells have recently been more clearly defined with the observation that Toll-like receptor 3 can sense self RNA released from necrotic keratinocytes following UV damage. TLR3 activation in the skin induces inflammation and increases the expression of genes involved in skin barrier repair. Activation of TLR2 in the skin by commensal microbial products prevents excessive inflammation by blocking… CONTINUE READING


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