Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells.

@article{Schwarz1995UltravioletBinducedAO,
  title={Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells.},
  author={Agatha Schwarz and Rhanjit S. Bhardwaj and Yoshinori Aragane and Karsten Mahnke and Helge Riemann and Dieter Metze and Thomas Anton Luger and Thomas Schwarz},
  journal={The Journal of investigative dermatology},
  year={1995},
  volume={104 6},
  pages={922-7}
}
Irradiation with ultraviolet (UV) B radiation results in the formation of apoptotic keratinocytes called sunburn cells. Recently, it was demonstrated that keratinocytes can release tumor necrosis factor-alpha (TNF-alpha), which is known to cause apoptosis in particular cells. In addition, it has been shown that UVB light induces the release of TNF-alpha by keratinocytes and that keratinocytes express the 55-kD receptor for TNF-alpha. Therefore, we investigated whether TNF-alpha is involved in… CONTINUE READING

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