Ultraviolet A regulates adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via up-regulation of Kruppel-like factor 2.

@article{Lee2010UltravioletAR,
  title={Ultraviolet A regulates adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via up-regulation of Kruppel-like factor 2.},
  author={Jongsung Lee and Jienny Lee and Eunsun Jung and Young-Soo Kim and Kyungbaeg Roh and K Jung and Deokhoon Park},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 42},
  pages={32647-56}
}
Adipocyte dysfunction is strongly associated with the development of obesity, which is a major risk factor for many disorders, including diabetes, hypertension, and heart disease. This study shows that ultraviolet A (UVA) inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells and its action mechanisms. The mRNA levels of peroxidase proliferator-activated receptor (PPAR) γ and CCAAT/enhancer-binding protein α (C/EBPα), but not CCAAT/enhancer-binding protein… CONTINUE READING

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