Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis.

@article{GretherBeck2005UltravioletAS,
  title={Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis.},
  author={Susanne Grether-Beck and Andreas Timmer and Ingo Felsner and Heidi Brenden and Daniela Brammertz and Jean Krutmann},
  journal={The Journal of investigative dermatology},
  year={2005},
  volume={125 3},
  pages={545-53}
}
Exposure of human keratinocytes to ultraviolet A (UVA) radiation at physiological doses leads to a biphasic activation of transcription factor activator protein-2 (AP-2) and subsequently to a biphasic increase in gene expression of, e.g. intercellular adhesion molecule-1 (ICAM-1). Both kinetics follow a pattern with a first peak between 0.5 and 2 h and a second, more sustained activation between 16 and 48 h. We have previously reported on a non-enzymatic triggering of the ceramide signaling… CONTINUE READING
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