Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts.

@article{Watanabe2004UltravioletAP,
  title={Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts.},
  author={Hirokazu Watanabe and Tadamichi Shimizu and Jun Nishihira and Riichiro Abe and Toshinori Nakayama and Masaru Taniguchi and H. Sabe and Teruo Ishibashi and Hiroshi Shimizu},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 3},
  pages={1676-83}
}
Matrix metalloproteinases (MMPs) are thought to be responsible for dermal photoaging in human skin. In the present study, we evaluated the involvement of macrophage migration inhibitory factor (MIF) in MMP-1 expression under ultraviolet A (UVA) irradiation in cultured human dermal fibroblasts. UVA (20 J/cm(2)) up-regulates MIF production, and UVA-induced MMP-1 mRNA production is inhibited by an anti-MIF antibody. MIF (100 ng/ml) was shown to induce MMP-1 in cultured human dermal fibroblasts. We… CONTINUE READING
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