Ultrastructure of spontaneous hyperplastic nodules in mouse liver.


The fine structure of parenchymatous cells in a series of spontaneous, hyperplastic nodules in aging C3H mice is described. These nodules were circumscribed, frequently lacked central and portal veins, and sometimes exhibited a variety of other changes including hydropic vacuolization, fatty infiltration, and dilation of sinusoids. The nuclei of the parenchymatous cells were smaller and more uniform in size while the cytoplasm was more basophilic and often vacuolated. All the nodules showed varying degrees of alteration in fine structure particularly in the Golgi apparatus and mitochondria. Most striking, however, were alterations in the rough endoplasmic reticulum in which the normally flattened cisternae were transformed into either a dilated or a tubular form, containing amorphous, granular, or filamentous material. The filaments measured about 33 m/¿ in diameter. Of interest is the fact that similar changes in the endoplasmic reticulum were also observed in an apparently "normal" liver from a mouse of the same age group. The nature

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@article{Essner1967UltrastructureOS, title={Ultrastructure of spontaneous hyperplastic nodules in mouse liver.}, author={Edward S. Essner}, journal={Cancer research}, year={1967}, volume={27 11}, pages={2137-52} }