Ultrastructure of sickling and unsickling in time-lapse studies.

  title={Ultrastructure of sickling and unsickling in time-lapse studies.},
  author={Janghee Hahn and M J Messer and Thomas B. Bradley},
  journal={British journal of haematology},
  volume={34 4},
The denser subpopulation of erythrocytes from patients with sickle cell anaemia was deoxygenated to a pO2 of 4.7 kPa or reoxygenated to a pO2 of 12 kPa with a continuous-flow apparatus. Samples were collected into modified Karnovsky's fixative at intervals between 0.5 and 15 S. .The earliest event after deoxygenation was aggreagation of haemoglobin followed… CONTINUE READING