Ultrastructure of pulmonary granulomatosis induced in rats by intravenous complete Freund's adjuvant

@article{Soler1975UltrastructureOP,
  title={Ultrastructure of pulmonary granulomatosis induced in rats by intravenous complete Freund's adjuvant},
  author={Paul Soler and Jean François Bernaudin and Françoise Basset},
  journal={Virchows Archiv A},
  year={1975},
  volume={368},
  pages={35-50}
}
Following the intravenous injection of complete Freund's adjuvant, changes in the rat lung were studied with the electron microscope. Interstitial granulomas were produced and whereas on light microscopy these appeared to consist mainly of epithelioid cells, electron microscopy showed that the granulomas were largely made up of macrophages. Epithelioid cells were in fact few in number, atypical in appearance and limited to the periphery of some granulomas. Fenestrated capillaries were also… CONTINUE READING