Ultrastructure of pityriasis rubra pilaris with observations during retinoid (etretinate) treatment.

@article{Kanerva1983UltrastructureOP,
  title={Ultrastructure of pityriasis rubra pilaris with observations during retinoid (etretinate) treatment.},
  author={Lasse Kanerva and Jorma Lauharanta and Kaisa Niemi and Allan Lassus},
  journal={The British journal of dermatology},
  year={1983},
  volume={108 6},
  pages={653-63}
}
The light and electron microscopic structure of pityriasis rubra pilaris (PRP) is described in five patients. Hyperkeratosis, hypergranulosis, keratotic plugs in the follicular openings, acanthosis and focal parakeratosis were observed. A moderate perivascular infiltrate was seen in the upper dermis. Electron microscopy revealed moderately activated keratinocytes, a decreased number of tonofilaments and desmosomes, enlarged intercellular spaces, parakeratosis with lipid-like vacuoles and a… CONTINUE READING